Marvis ‘ toothpaste, packaged in an apothecary tube, is made in Florence, Italy, where the brand has been a trusted favorite for generations. Designed specifically to freshen breath and whiten teeth, this cool mint-flavored formula is just what you need for a mega-watt smile. Instructions for use Brush twice a day for at least two minutes each time. Replace your toothbrush every 2-3 months.